User contributions for Nikolas

11:0711:07, 18 June 2024 diff hist +80‎ Therapeutic drug monitoring ‎No edit summary current
11:0611:06, 18 June 2024 diff hist +500‎ N Therapeutic drug monitoring ‎ Created page with "{{:Stub}} = measurement of drug concentration or activity in plasma * Methods ** High performance liquid chromatography ** Immunoassay * Indications ** Non-linear kinetics of drug ** When there is poor compliance ** If the therapeutic effect can’t be assessed clinically ** If the therapeutic index is low *** Warfarin *** Aminoglycosides *** Antipsychotics *** Digoxin *** Lithium ** When there are signs of overdose ** To determine pharmacokinetic interactions Categ..." Tag: Visual edit
11:0511:05, 18 June 2024 diff hist +54‎ 49. Molecular biology applications in the practice of clinical laboratories ‎No edit summary current Tag: Visual edit
11:0411:04, 18 June 2024 diff hist +736‎ N 49. Molecular biology applications in the practice of clinical laboratories ‎ Created page with "Molecular biology methods * High sensitivity and specificity * Expensive * Real-time PCR ** Visualization – fluorescent dyes, hybridization * DNA sequencing ** Next generation sequencing ** Whole exome sequencing * Benefit * Diagnosis ** Prognosis ** Therapy response * Monogenic disorders ** Sickle cell anaemia ** Thalassaemia * Microbiological assays ** HepC ** HepB ** CMV ** <abbr>EBV</abbr> ** HSV ** Gonorrhoea * Inherited conditions ** Factor V Leiden ** Prothr..." Tag: Visual edit
11:0211:02, 18 June 2024 diff hist +93‎ N 48. Tumor markers and their informational value in the clinical laboratory practice ‎ Created page with "{{#lst:Tumour marker|clinical biochemistry}} Category:Clinical Biochemistry (POTE course)" current Tag: Visual edit
11:0211:02, 18 June 2024 diff hist +896‎ Tumour marker ‎No edit summary Tag: Visual edit: Switched
10:5510:55, 18 June 2024 diff hist +46‎ N Afp ‎ Redirected page to Tumour marker#Alpha-foetoprotein current Tags: New redirect Visual edit
10:5210:52, 18 June 2024 diff hist +53‎ N PSA ‎ Redirected page to Tumour marker#Prostate specific antigen current Tags: New redirect Visual edit
10:5210:52, 18 June 2024 diff hist +53‎ N Prostate specific antigen ‎ Redirected page to Tumour marker#Prostate specific antigen current Tags: New redirect Visual edit
10:5110:51, 18 June 2024 diff hist −1,361‎ 49. Clinical aspects of neoplasm. Paraneoplastic syndromes, tumour markers ‎ →‎Tumour markers Tag: Visual edit: Switched
10:5110:51, 18 June 2024 diff hist +3,834‎ N Tumour marker ‎ Created page with "<section begin="pathology" />A '''tumour marker''', also called a '''cancer biomarker''', is a substance found in the body which concentration in the blood or other body fluid increases when cancer is present. The tumour marker may be produced by the cancer cells themselves or by healthy cells in response to the cancer. Tumour markers are usually proteins and are often produced in small amounts even in people without cancer. The term tumour marker may also be used to..." Tag: Visual edit: Switched
10:2710:27, 18 June 2024 diff hist +28‎ N Cancer treatment ‎ Redirected page to Cancer therapy current Tags: New redirect Visual edit
10:1310:13, 18 June 2024 diff hist +557‎ N 47. The most important non-specific laboratory tests that suggest the presence of malignant diseases. ‎ Created page with "* In any cancer ** Elevated CRP or ESR (without infection or other explanatory cause) * Multiple myeloma ** Extremely high ESR * GI cancer ** Chronic microcytic anaemia * Leukaemias ** Leukocytosis ** Anaemia ** Thrombocytopaenia ** Blasts in bone marrow or blood ** Abnormal differentiation * Bone tumors ** ALP increase * Lung cancer ** LDH increase * Bile duct cancer ** Bilirubin increase * Neuroendocrine tumors ** Hormones * During chemo ** Bone marrow depression ** LD..." current Tag: Visual edit
10:0910:09, 18 June 2024 diff hist +221‎ N 46. Clinical biochemistry of the disorders of the human reproductive system ‎ Created page with "= Assessment of ovarian reserve = {{#lst:Infertility (female)|clinical biochemistry}} = Polycystic ovary syndrome = {{#lst:Polycystic ovary syndrome|clinical biochemistry}} Category:Clinical Biochemistry (POTE course)" current Tag: Visual edit
10:0810:08, 18 June 2024 diff hist −1‎ Infertility (female) ‎No edit summary current
10:0810:08, 18 June 2024 diff hist −4,028‎ B12. Infertility; classifications and diagnosis ‎ Replaced content with "{{#lst:Infertility (female)|infertility}} See also topic B4. Category:Obstetrics and gynaecology 2" current Tags: Replaced Visual edit
10:0710:07, 18 June 2024 diff hist −2,633‎ B4. Functional diagnostics of the ovarian capacity, cycle diagnostic ‎ Replaced content with "These investigations are mostly relevant for the evaluation of infertility (see topic B12). {{#lst:Infertility (female)|ovarian capacity}} Category:Obstetrics and gynaecology 2" current Tags: Replaced Visual edit
10:0710:07, 18 June 2024 diff hist +210‎ Infertility (female) ‎No edit summary
10:0510:05, 18 June 2024 diff hist +6,876‎ N Infertility (female) ‎ Created page with "'''Female''' '''infertility''' is defined as the inability of a couple to conceive with regular intercourse without use of contraception after 12 months in women less then 35 years of age, and after 6 months in women 35 years and older. We can distinguish primary and secondary infertility. In primary, the woman has never achieved pregnancy, while in secondary, there’s been at least one previous pregnancy. Fecundability is also relevant. It’s the probability of achi..." Tag: Visual edit
07:0907:09, 18 June 2024 diff hist +230‎ 37. Laboratory diagnosis of acute renal diseases. ‎No edit summary current Tag: Visual edit

15:3215:32, 30 May 2024 diff hist +39‎ N PCOS ‎ Redirected page to Polycystic ovary syndrome current Tags: New redirect Visual edit
15:2415:24, 30 May 2024 diff hist −2,858‎ B11. Hyperandrogenic disorders, PCOS ‎No edit summary current Tag: Visual edit
15:2315:23, 30 May 2024 diff hist +23‎ Polycystic ovary syndrome ‎No edit summary current
15:2315:23, 30 May 2024 diff hist +2,909‎ N Polycystic ovary syndrome ‎ Created page with "<section begin="clinical biochemistry" />'''Polycystic ovary syndrome''' (PCOS) is characterised by oligomenorrhoea, hyperandrogenism, and anovulation. It’s a common disorder, as it affects approx. 10% of women. It’s the most common cause of hyperandrogenism in females. Symptoms usually begin in adolescence.<section end="clinical biochemistry" /> == Risk factors == * Obesity * Diabetes mellitus * Family history == Pathomechanism == The pathomechanism is unknown. O..." Tag: Visual edit
15:2115:21, 30 May 2024 diff hist +160‎ B11. Hyperandrogenic disorders, PCOS ‎No edit summary
15:1915:19, 30 May 2024 diff hist +80‎ B4. Functional diagnostics of the ovarian capacity, cycle diagnostic ‎No edit summary
15:1615:16, 30 May 2024 diff hist +946‎ N 45. Clinical biochemistry of the disorders of adrenal medulla/cortex ‎ Created page with "* Adrenal cortex ** Hypofunction *** Hyponatraemia *** Hyperkalaemia *** Metabolic acidosis *** Addison disease **** Low cortisol **** ACTH high **** ACTH stimulation -> cortisol remains low (usually rises) *** Secondary/tertiary adrenal insufficiency **** Low cortisol **** ACTH low **** ACTH stimulation -> cortisol increases *** Congenital adrenal hyperplasia **** High levels of 17-hydroxyprogesterone ** Hyperfunction *** Hypernatraemia *** Hypokalaemia *** Metabolic al..." current Tag: Visual edit
15:1615:16, 30 May 2024 diff hist +469‎ N 44. Laboratory assessment of the thyroid function ‎ Created page with "= Hypothyroidism = {{#lst:Hypothyroidism|clinical biochemistry}} = Hyperthyroidism and thyrotoxicosis= {{#lst:Hyperthyroidism and thyrotoxicosis|clinical biochemistry}} = Hashimoto thyroiditis = {{#lst:Hashimoto thyroiditis|clinical biochemistry}} = Other stuff = * Drugs which affect thyroid function ** Lithium – decreases thyroid hormone release ** Amiodarone – hypo or hyperthyroidism ** SSRIs – increase TSH Category:Clinical Biochemistry (POTE course)" current Tag: Visual edit
15:1315:13, 30 May 2024 diff hist +160‎ Hashimoto thyroiditis ‎No edit summary current
15:1315:13, 30 May 2024 diff hist +160‎ Hypothyroidism ‎No edit summary current
15:1215:12, 30 May 2024 diff hist +466‎ Hyperthyroidism and thyrotoxicosis ‎No edit summary Tag: Visual edit: Switched
15:1115:11, 30 May 2024 diff hist +192‎ Hypothyroidism ‎No edit summary Tag: Visual edit
14:5814:58, 30 May 2024 diff hist +651‎ N 43. Clinical biochemistry of the hypothalamus, hypophysis ‎ Created page with "* Dynamic function test ** Administer insulin -> measure cortisol, GH ** Administer GnRH -> measure FSH, LH ** Administer TRH -> measure TSH * GH excess ** Administer oral glucose -> GH still high (usually decreases) * GH deficiency ** Low levels of <abbr>IGF</abbr>-1 ** Administer GHRH -> GH still low (usually increases) * Hyperprolactinaemia ** Serum prolactin ** Administer dopamine agonist -> prolactin still high (usually decreases) * Diabetes insipidus ** Water depri..." current Tag: Visual edit
14:5614:56, 30 May 2024 diff hist +1,271‎ N 42. Pre-analytical considerations of the hormone tests. ‎ Created page with "* Measured by serum in plain tube (red) or gel tube (yellow) * Small peptide hormones ** Unstable, transported quickly and on ice ** TRH ** Renin * Amino acid derivatives ** T3, T4 *** Only free fraction is measured *** Protein binding influences measurement ** Adrenalin * Steroids ** Cortisol ** Aldosterone ** Sex hormones ** Both fractions are measured *** Binding protein should also be measured * Biological variation ** GH – pulsatile release ** Cortisol – influen..." current Tag: Visual edit

21:0221:02, 28 May 2024 diff hist +58‎ Main Page ‎No edit summary Tag: Visual edit
21:0121:01, 28 May 2024 diff hist +32‎ N File:Flag of Palestine.png ‎No edit summary current
20:3720:37, 28 May 2024 diff hist −27‎ MediaWiki:Sidebar ‎No edit summary
20:3220:32, 28 May 2024 diff hist −573‎ Main Page ‎No edit summary Tag: Visual edit
19:5119:51, 28 May 2024 diff hist +21‎ 16. Neurulation. The structure of the neural tube. Development of the spinal cord ‎No edit summary current Tag: Visual edit
10:1610:16, 28 May 2024 diff hist +189‎ N 41. Laboratory tests of the cerebrospinal fluid and other body fluids. ‎ Created page with "= Cerebrospinal fluid = {{#lst:cerebrospinal fluid|clinical biochemistry}} = Pleural fluid = {{#lst:Pleural effusion|clinical biochemistry}} Category:Clinical Biochemistry (POTE course)" current Tag: Visual edit
10:1510:15, 28 May 2024 diff hist +3,035‎ Pleural effusion ‎No edit summary current Tag: Visual edit: Switched
09:5409:54, 28 May 2024 diff hist +4‎ Liver biochemical tests ‎No edit summary current Tag: Visual edit
09:5309:53, 28 May 2024 diff hist 0‎ Erythrocyte sedimentation rate ‎No edit summary current Tag: Visual edit
09:5209:52, 28 May 2024 diff hist +50‎ N Leukocyte count ‎ Redirected page to Leukocyte#Leukocyte count (lab test) current Tags: New redirect Visual edit
09:5209:52, 28 May 2024 diff hist +8‎ Leukocyte ‎No edit summary current Tag: Visual edit

10:0310:03, 27 May 2024 diff hist +753‎ Lumbar puncture ‎No edit summary current Tag: Visual edit: Switched
09:5209:52, 27 May 2024 diff hist +29‎ N Cerebrospinal fluid ‎ Redirected page to Lumbar puncture current Tags: New redirect Visual edit
09:4909:49, 27 May 2024 diff hist +89‎ N 40. Laboratory assessment of increased serum uric acid levels ‎ Created page with "{{#lst:Uric acid|clinical biochemistry}} Category:Clinical Biochemistry (POTE course)" current Tag: Visual edit
09:4909:49, 27 May 2024 diff hist +836‎ N Uric acid ‎ Created page with "<section begin="clinical biochemistry" />'''Uric acid''' (or '''urate''') is a metabolic breakdown product of purines. Purines are metabolised to xanthine and then to uric acid by xanthine oxidase. Deposition of uric acid crystals in joints is the driving mechanism in attacks of gout. Deposition of uric acid crystals in the kidney can cause uric acid nephropathy. Elevated uric acid is seen in gout, but is also seen in tumour lysis syndrome, ..." current Tag: Visual edit: Switched
09:4009:40, 27 May 2024 diff hist +164‎ N 39. Laboratory findings in proteinuria and haematuria ‎ Created page with "= Proteinuria = {{#lst:Proteinuria|clinical biochemistry}} = Haematuria = {{#lst:Haematuria|clinical biochemistry}} Category:Clinical Biochemistry (POTE course)" current Tag: Visual edit

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