43. Clinical biochemistry of the hypothalamus, hypophysis

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  • Dynamic function test
    • Administer insulin -> measure cortisol, GH
    • Administer GnRH -> measure FSH, LH
    • Administer TRH -> measure TSH
  • GH excess
    • Administer oral glucose -> GH still high (usually decreases)
  • GH deficiency
    • Low levels of IGF-1
    • Administer GHRH -> GH still low (usually increases)
  • Hyperprolactinaemia
    • Serum prolactin
    • Administer dopamine agonist -> prolactin still high (usually decreases)
  • Diabetes insipidus
    • Water deprivation -> urine osmolality unchanged (usually increases)
    • Administer desmopressin -> urine osmolality increases (normalizes)