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10. Rapidly progressive GN with crescents: Difference between revisions
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(Created page with "'''Staining''': HE '''Organ''': Kidney '''Description''': Almost all glomeruli in the slide contain some degree of fibrocellular tissue. Some glomeruli have this tissue in a half-moon-like formation called ''crescents''. The finding of crescents is associated with RPGN. '''Diagnosis''': Rapidly progressing glomerulonephritis (RPGN) '''Causes''': # Goodpasture syndrome # Immune complex mediated ## <abbr>SLE</abbr> ## Rheumatic fever ## <abbr>IgA</abbr> nephropathy #...") |
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'''Staining''': HE | [[File:RPGN - overview.png|thumb|Overview|312x312px]]'''Staining''': HE | ||
'''Organ''': Kidney | '''Organ''': Kidney | ||
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## <abbr>IgA</abbr> nephropathy | ## <abbr>IgA</abbr> nephropathy | ||
# Pauci-immune | # Pauci-immune | ||
[[File:RPGN - glomerulus.png|thumb|(Mostly) normal glomerulus. The glomerular tuft occupies mostly the whole Bowman’s space.]]'''Theory''': | |||
'''Theory''': | |||
Crescents are formed by proliferation of parietal cells and by migration of macrophages into the Bowman’s space. They are comprised of macrophages, fibroblasts, fibrosis and possibly necrosis. | Crescents are formed by proliferation of parietal cells and by migration of macrophages into the Bowman’s space. They are comprised of macrophages, fibroblasts, fibrosis and possibly necrosis. | ||
Rapidly progressing glomerulonephritis causes rapid renal failure within days. Diagnosis is based on histology. | Rapidly progressing glomerulonephritis causes rapid renal failure within days. Diagnosis is based on histology. | ||
[[File:RPGN - glomerulus2.png|thumb|Another glomerulus|left]] | |||
[[File:RPGN - glomerulus3.png|thumb|A third glomerulus]] | |||
[[File:RPGN - glomerulus2.png | |||
[[File:RPGN - glomerulus3.png | |||
[[Category:Pathology 2 - Histopathology slides]] | [[Category:Pathology 2 - Histopathology slides]] | ||