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22. Fibrinous pericarditis – cor villosum: Difference between revisions
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'''Theory''': The fibrinous exudate caused by the fibrinous acute inflammation is mostly degraded by fibrinolysis and macrophages, a process called resolution. However, the fibrin-rich exudate is not completely removed and is instead replace by fibroblasts and blood vessels invading the exudate to form fibrosis. This is the process called organization. | '''Theory''': The fibrinous exudate caused by the fibrinous acute inflammation is mostly degraded by fibrinolysis and macrophages, a process called resolution. However, the fibrin-rich exudate is not completely removed and is instead replace by fibroblasts and blood vessels invading the exudate to form fibrosis. This is the process called organization. | ||
The fifth layer (layer 5) shows the ''active'' phase of the pericarditis. It’s comprised of only neutrophils (due to the inflammation) and fibrin. Fibrin, being a protein, is very eosinophilic under the microscope. | The fifth layer (layer 5) shows the ''active'' phase of the pericarditis. It’s comprised of only neutrophils (due to the inflammation) and fibrin. Fibrin, being a protein, is very eosinophilic under the microscope.[[File:Fibrinous pericarditis - layer 4.jpg|thumb|Close-up of layer 4. You can see loose connective tissue and fibrin. In the top left you can see a part of the fifth layer.]]The fourth layer shows the ''early phase of organization'' after the pericarditis. This layer is where organization happens. It is paler than the fifth layer because this layer doesn’t contain just fibrin, but loose connective tissue as well, made by invading fibroblasts. | ||
The third layer shows the ''late phase of organization''. In this layer, fibrosis has already started. The second and first layers are normal. The fibrous scar tissue forming in the pericardium can restrict the function of the myocardium.[[File:Fibrinous pericarditis - layer 3.jpg|thumb|Close-up of layer 3. Fibrosis.|left]] | |||
The third layer shows the ''late phase of organization''. In this layer, fibrosis has already started. The second and first layers are normal. The fibrous scar tissue forming in the pericardium can restrict the function of the myocardium. | |||
[[File:Fibrinous pericarditis - layer 3.jpg|thumb|Close-up of layer 3. Fibrosis.]] | |||
[[Category:Pathology 1 - Histopathology slides]] | [[Category:Pathology 1 - Histopathology slides]] | ||