Diffuse large B-cell lymphoma

Diffuse large B-cell lymphoma (DLBCL) is an aggressive non-Hodgkin lymphoma and the most common NHL overall. It may develop de novo or secondary to transformation from an indolent B-cell NHL, often CLL/SLL (in which case it’s called Richter transformation) or follicular lymphoma. The de novo type has better prognosis than the secondary.