Bone

This article is a stub, meaning that it is unfinished. It will eventually be expanded.

• bone
  • 65% minerals (hydroxyapatite)
  • 35% matrix
    • Collagen
    • Osteoblasts
    • Osteoclasts

• Markers
  • High biological and analytical variability
    • Diurnal variation
    • Seasonal variation
    • Food intake
    • Exercise
  • Made in same lab, collected at same time
• Markers of bone formation
  • Total alkaline phosphatase
  • Bone specific alkaline phosphatase
  • Osteocalcin – increased in high bone turnover
  • Procollagen propeptides
    • PICP – procollagen type I C-terminal
    • PINP – procollagen type I N-terminal

• Markers of bone resorption
  • Urine (corrected for creatinine)
    • Deoxypyridinoline (cross-linking collagen cleavage products)
    • N-terminal cross links (NTX) – N-telopeptide of type I collagen
    • C-terminal cross links (CTX) – C-telopeptide of type I collagen
  • Serum
    • TRACP5b – tartate resistant acid phosphatase
  • Serum and urine
    • beta-crosslaps