B5. Clinical forms and treatment of Kaposi sarcoma

From greek.doctor
  • Caused by HHV8, immunosuppression is risk factor
  • Malignant tumor of endothelial cells
  • 4 types
    • Classic – in older males
    • Endemic – in Africa
    • Immunosuppressive therapy-related
    • AIDS-related
  • Clinical features
    • Multiple cutaneous lesions
      • Purplish macules -> patches -> papules -> plaques -> nodules
    • Rapidly growing
    • Initially seen on face, oral cavity or chest
    • Organs can be involved
  • Treatment
    • Classic KS -> surgery or radiotherapy
    • HIV-related KS -> treatment of AIDS alone may cause cancer regression
    • KS associated with non-HIV immunosuppression -> changing immunosuppressing drug alone may cause regression