B4. Symptoms, diagnosis and treatment of non-gonorrhoeic urethritis
Chlamydia
Chlamydia is most common STD, if you don’t count HPV. It’s caused by Chlamydia trachomatis serotypes D-K. It may progress to pelvic inflammatory disease.
Clinical features
90% of affected people are asymptomatic. Possible symptoms in women include:
- Urethritis with dysuria
- Mucopurulent discharge
- Postcoital bleeding
Men may experience prostatitis and epididymitis.
Diagnosis and evaluation
PCR of vaginal swab.
Treatment
Single dose 1 g PO azithromycin or doxycyclin for 7 days.
Complications
Reiter syndrome/reactive arthritis is a complication of many bacterial infections, most commonly after chlamydia. It’s associated with HLA-B27 and mostly affects young males. It’s characterised by a clinical triad of:
- Arthritis
- Conjunctivitis
- Urethritis
Trichomoniasis
Trichomoniasis is a sexually transmitted infection caused by trichomonas vaginalis.
Clinical features
It’s asymptomatic in 70%. Foul-smelling, yellow-green coloured vaginal discharge is highly suspicious for trichomoniasis. Other symptoms include:
- Itching
- Burning
- Dyspareunia
- Itchiness
- Redness
- Strawberry cervix – typical appearance of cervix like a strawberry
Diagnosis and evaluation
Physical examination may reveal characteristic appearance or odour.
pH measurement is also important. The pH of the vagina is normally 4 – 4,5, but in case of bacterial vaginosis or trichomoniasis, the pH is > 4,5. The Amine test (for bacterial vaginosis) is positive here as well.
Vaginal smear, the examination of vaginal fluid under the microscope, may also be performed. For trichomoniasis, motile organisms with multiple flagella are visible.
Treatment
Metronidazole is the first line treatment for both the patient and the partner. A single dose 2g p.o. metronidazole may be used.