B18. Cutaneous T-cell lymphomas

From greek.doctor
  • Mycosis fungoides
    • CD4+ T-cell lymphoma
    • Progresses slowly
    • Stage I – patch stage
      • Scaly, pruritic, well-demarcated patches
    • Stage II – plaque stage
      • Scaly, pruritic, well-demarcated plaques
      • Large
    • Stage III – tumor stage
      • Dome-shaped purple or red nodules
    • Treatment
      • Topical steroids
      • Topical chemo
      • Phototherapy
      • Biological therapy
      • Systemic chemo
  • Sézary syndrome
    • Can develop from mycosis fungoides or de novo
    • Clinical triad
      • Systemic skin lesions
        • Erythroderma
        • Palmar and plantar hyperkeratosis
        • Pruritus
      • Generalized lymphadenopathy
      • Atypical T-cells in blood
    • Treatment
      • Extracorporal photopheresis
      • Phototherapy
      • Chemotherapy
  • Adult cutaneous T-cell leukaemia/lymphoma
    • HTLV-I associated
    • Similar lesions to mycosis fungoides