44. Brain perfusion examinations in nuclear medicine (indications, radiopharmaceuticals, imaging).

From greek.doctor
  • Modalities
    • Brain scintigraphy
      • 99mTc-DTPA
      • Used for confirmation of brain death
    • Brain perfusion scintigraphy
      • With SPECT
      • 99mTc-HM-PAO – accumulates in gray matter
      • Indications
        • Cerebrovascular disease
        • Dementia
    • CSF scintigraphy
      • 99mTc-DTPA intrathecally
      • Indications
        • Spinal tumor
        • Hydrocephalus
    • Brain receptor scintigraphy
      • 123I-ioflupane – Binds to dopamine transporter
      • 123I-IBZM (DaTscan) – Binds to D2 receptors
        • Both are used to differentiate Parkinson from other neurodegenerative diseases
    • Brain metabolism (PET investigation)
      • 18F-FDG or 11C-methionine
      • Examination of brain tumors