26. Epidemiology and prevention of inflammatory bowel diseases

From greek.doctor
  • IBD
    • Epidemiology
      • More common in urbanized areas of Western countries
      • Higher incidence in northern than southern countries
      • White, Ashkenazi Jews
      • Age of onset 15 – 30
      • Women = men
    • Etiology
      • Physical inactivity
      • Diet
        • Low intake of fibre
        • High intake of fat
        • Vitamin D deficiency
      • Hygiene hypothesis
        • Extremely hygienic environments predispose to immunological diseases
      • Family history
      • High socioeconomic status
      • Urbanization
      • Drugs
        • Contraceptives
        • NSAIDs
    • Prognosis
      • No cure
      • Mortality similar to healthy
      • Needs a lifetime of care
      • Requires many physician visits, hospitalizations
      • Major cause of disability
    • Prevention
      • Tertiary
  • Crohns
    • Epidemiology
      • Prevalence: 300 / 100 000
      • Incidence: 24 / 100 000
    • Specific risk factors
      • Smoking
      • NOD2
    • Prognosis
      • 75% require surgery
  • UC
    • Epidemiology
      • Prevalence: 500 / 100 000
      • Incidence: 12 / 100 000
    • Specific risk factors
      • Not smoking
    • Prognosis
      • 25% require surgery