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Metabolic acidosis: Difference between revisions
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<section begin="clinical biochemistry" />{{Infobox medical condition | <section begin="A&IC" /><section begin="clinical biochemistry" />{{Infobox medical condition | ||
| name = Metabolic acidosis | | name = Metabolic acidosis | ||
| definition = A process decreasing pH due to metabolic process | | definition = A process decreasing pH due to metabolic process | ||
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=== Ketoacidosis === | === Ketoacidosis === | ||
Ketoacidosis refers to metabolic acidosis due to accumulation of [[ketone bodies]], which are acidic. Ketone bodies are the body's "reserve fuel" when glucose availability is limited or available glucose cannot be metabolised. Accumulation of ketone bodies may occur in case of severe fasting, for example due to [[alcohol]] abuse, or due to uncontrolled or untreated [[type 1 diabetes mellitus]]. In type 1 DM, there is hyperglycaemia, so lack of glucose is not a problem. Instead, there is insulin deficiency, and insulin is required for cells to take in and metabolise glucose. | Ketoacidosis refers to metabolic acidosis due to accumulation of [[ketone bodies]], which are acidic. Ketone bodies are the body's "reserve fuel" when glucose availability is limited or available glucose cannot be metabolised. Accumulation of ketone bodies may occur in case of severe fasting, for example due to [[alcohol]] abuse, or due to uncontrolled or untreated [[type 1 diabetes mellitus]]. In type 1 DM, there is hyperglycaemia, so lack of glucose is not a problem. Instead, there is insulin deficiency, and insulin is required for cells to take in and metabolise glucose. | ||
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== Complications == | == Complications == | ||
Severe acidaemia can cause fatal [[Ventricular arrhythmias|ventricular arrhythmia]] and depression of cardiac contractility, which may cause heart failure. | Severe acidaemia can cause fatal [[Ventricular arrhythmias|ventricular arrhythmia]] and depression of cardiac contractility, which may cause heart failure.<section end="A&IC" /> | ||
[[Category:Pathophysiology]] | [[Category:Pathophysiology]] | ||