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35. Polypus adenomatosus coli (p53): Difference between revisions
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(Created page with "'''Staining''': Immunohistochemistry targeting the protein p53 '''Organ''': Colon '''Description''': Three sections can be seen. We’ll call the lower right section for section 1. Here we can see colonic crypts, and no villi. Goblet cells are present. Section 2 is the section above. Here we can see that the crypts contain bubble-like structures. No goblets cells are present. The interesting part about section 3 is the epithelium that is stained brown. The staining...") |
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'''Staining''': Immunohistochemistry targeting the protein p53 | [[File:Adenomatous colon polyp, p53 staining overview.png|thumb|Overview. 1 is from healthy colon, 2 and 3 are from a polyp.]]'''Staining''': Immunohistochemistry targeting the protein p53 | ||
'''Organ''': Colon | '''Organ''': Colon | ||
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The interesting part about section 3 is the epithelium that is stained brown. The staining is inside the nuclei and not in the cytosol of the stained cells. Also notice that the stalk in section 3. Otherwise is it similar to section 2. | The interesting part about section 3 is the epithelium that is stained brown. The staining is inside the nuclei and not in the cytosol of the stained cells. Also notice that the stalk in section 3. Otherwise is it similar to section 2. | ||
'''Diagnosis''': Adenomatous polyp in the colon | '''Diagnosis''': Adenomatous polyp in the colon[[File:Adenomatous colon polyp, p53 staining comparison.jpg|thumb|Comparison between the healthy colon and the polyp. The tubular structure show that this is a tubular polyp.]]'''Risk factors:''' | ||
'''Risk factors:''' | |||
* Inflammatory bowel disease | * Inflammatory bowel disease | ||
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* According to their microscopical features (tubular/villous/tubulovillous) | * According to their microscopical features (tubular/villous/tubulovillous) | ||
* Whether dysplasia is present or not (hyperplastic/adenomatous) | * Whether dysplasia is present or not (hyperplastic/adenomatous) | ||
[[File:Adenomatous colon polyp, p53 staining close-up.png|thumb|Note how it is the nuclei that contain p53 and not the cytosol. p53 is a nuclear protein.]]Polyps that look like mushrooms growing out of the mucosa are called ''pedunculated'' polyps. They have stalks that separate them from the colonic mucosa. Polyps that don’t have stalks and instead diffusely grow out of the mucosa are called ''sessile'' polyps. Pedunculated polyps are easier to remove, due to their stalk. | |||
Polyps that look like mushrooms growing out of the mucosa are called ''pedunculated'' polyps. They have stalks that separate them from the colonic mucosa. Polyps that don’t have stalks and instead diffusely grow out of the mucosa are called ''sessile'' polyps. Pedunculated polyps are easier to remove, due to their stalk. | |||
Polyps that have the tubular structures seen in this slide are called ''tubular'' polyps. Polyps can also have villi on their surface, then they’re called ''villous'' polyps. Polyps with both villi and tubular structure are called ''tubulovillous'' polyps. | Polyps that have the tubular structures seen in this slide are called ''tubular'' polyps. Polyps can also have villi on their surface, then they’re called ''villous'' polyps. Polyps with both villi and tubular structure are called ''tubulovillous'' polyps. | ||
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To summarize: The polyp in this slide is a tubular, pedunculated, adenomatous polyp that is p53 positive. | To summarize: The polyp in this slide is a tubular, pedunculated, adenomatous polyp that is p53 positive. | ||
[[Category:Pathology 1 - Histopathology slides]] | [[Category:Pathology 1 - Histopathology slides]] | ||