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Coeliac disease: Difference between revisions
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(Created page with "Coeliac disease, also called coeliac sprue or gluten-sensitive enteropathy, is a chronic immune-mediated systemic disorder triggered by consumption of gluten. It’s a relatively common condition, affecting 1 per 100 in Western Europe, but it’s also common in the Middle East. The prevalence has increased significantly in the recent 50 years. It’s likely underdiagnosed due to its heterogenous clinical presentation. == Etiology == Coeliac disease is highly related to...") |
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Coeliac disease, also called coeliac sprue or gluten-sensitive enteropathy, is a chronic immune-mediated systemic disorder triggered by consumption of gluten. | '''Coeliac disease''', also called '''coeliac sprue''' or '''gluten-sensitive enteropathy''', is a chronic immune-mediated systemic disorder triggered by consumption of gluten. | ||
It’s a relatively common condition, affecting 1 per 100 in Western Europe, but it’s also common in the Middle East. The prevalence has increased significantly in the recent 50 years. It’s likely underdiagnosed due to its heterogenous clinical presentation. | It’s a relatively common condition, affecting 1 per 100 in Western Europe, but it’s also common in the Middle East. The prevalence has increased significantly in the recent 50 years. It’s likely underdiagnosed due to its heterogenous clinical presentation. | ||
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== Diagnosis and evaluation == | == Diagnosis and evaluation == | ||
For diagnosis of coeliac disease, the patient must be on a gluten-containing diet for some time, to allow the pathological signs to appear. Presence of anti-tTG, anti-EMA, and anti-DGP antibodies is characteristic but unfortunately not diagnostic alone for coeliac disease, except in children. In adults, upper endoscopy with biopsy is required for the diagnosis. | For diagnosis of coeliac disease, the patient must be on a gluten-containing diet for some time, to allow the pathological signs to appear. Presence of anti-tTG, anti-EMA, and anti-DGP antibodies is characteristic but unfortunately not diagnostic alone for coeliac disease, except in children. In adults, [[upper endoscopy]] with biopsy is required for the diagnosis. | ||
Histological severity is classified according to the Marsh classification from Marsh 1 to 3c. | Histological severity is classified according to the Marsh classification from Marsh 1 to 3c. | ||