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35. Pharmacology of eicosanoids. Drugs acting on smooth muscle: Difference between revisions

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35. Pharmacology of eicosanoids. Drugs acting on smooth muscle (view source)

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(Created page with "== Eicosanoids == thumb|318x318px|Synthesis of eicosanoids. You already know these bad boys, prostaglandins, thromboxanes and leukotrienes. They’re synthesized from membrane phospholipids, which are first converted into arachidonic acid by ''phospholipase A2''. These molecules are very short-lived, meaning that they’re rapidly broken down in plasma after they’re produced. Their half-life is only 1 minute! They’re called eicosano...")
 
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=== Aspirin asthma ===
=== Aspirin asthma ===
Leukotrienes are involved in the development of NSAID-induced airway obstruction, so-called "aspirin-exacerbated respiratory disease" or “aspirin asthma”. When COX is inhibited, all the arachidonic acid molecules that are produced will be converted into leukotrienes. Leukotrienes cause swelling, increased mucus secretion and bronchoconstriction in the bronchi, causing asthma. Aspirin-exacerbated respiratory disease only occurs in a small percentage of people.
Leukotrienes are involved in the development of NSAID-induced airway obstruction, so-called "aspirin-exacerbated respiratory disease" or “aspirin asthma”.


== Prostanoid analogues ==
== Prostanoid analogues ==