Cutaneous lupus erythematosus
- Chronic discoid lupus erythematosus (CDLE)
- Epidemiology
- Most common cutaneous type
- African American women
- Clinical features
- Erythematous scaling plaques
- -> leaves atrophic scars
- Ocular and mucosal lesions
- Affects face, scalp, neck (sun-exposed areas)
- No systemic symptoms
- Epidemiology
- Subacute cutaneous lupus erythematosus (SCLE)
- Clinical features
- Persisting diffuse erythema on face or sun-exposed areas
- Annular or psoriasiform erythematous plaques
- Morbilliform rash on trunk
- Affects neck, shoulders, forearms
- Diagnosis
- Anti-Ro antibody
- Clinical features
- Drug-induced lupus erythematosus (DILE)
- Resolves after discontinuation of the drug
- In elderly
- May occur years after starting the drug
- Etiology
- Sulpha drugs
- Thiazides
- Sulfamethoxazole
- Sulfasalazine
- Sulfonylurea
- Methyldopa
- Isoniazid
- Especially slow acetylators
- Phenytoin
- Sulpha drugs
- Clinical features
- Rash
- Myalgia
- Fever
- Polyarthritis
- Serositis
- Diagnosis
- Anti-histone antibodies
- Treatment of cutaneous lupus erythematous
- Hydroxychloroquine
- Steroids
- Immunosuppressants
- Sunscreen