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39. Complex sclerosing lesion: Difference between revisions
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(Created page with "'''Staining''': HE '''Organ''': Breast '''Description''': There is a central lesion of fibrosis/fibroelastosis, with nodules of epithelial hyperplasia around. The fibrosis has a star-like shape, which is why it’s often described as a stellate lesion. Among the epithelial cells in the nodules, spindle-shaped cells can be seen. These cells are myoepithelial cells. The epithelial cells show no or only mild atypia. '''Diagnosis''': Complex sclerosing lesion '''Causes...") |
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'''Staining''': HE | [[File:Complex sclerosing lesion - overview.png|thumb|Overview]]'''Staining''': HE | ||
'''Organ''': Breast | '''Organ''': Breast | ||
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* Nothing in particular. | * Nothing in particular. | ||
'''Theory''': | '''Theory''':[[File:Complex sclerosing lesion - high magnification.png|thumb|Close-up]]This is a type of fibrocystic lesions. Complex sclerosing lesion is not a harmful condition, however it can cause similar clinical features as invasive breast cancer and must therefore be distinguished from it. Both can cause a palpable nodule and skin retraction. | ||
This is a type of fibrocystic lesions. Complex sclerosing lesion is not a harmful condition, however it can cause similar clinical features as invasive breast cancer and must therefore be distinguished from it. Both can cause a palpable nodule and skin retraction. | |||
The importance of this tumor-like lesion is therefore to distinguish it from cancer. As myoepithelial cells are not present in cancer, we can be certain that this slide is a complex sclerosing lesion and not a tumor. Also, the very mild degree of atypia here is not suggestive of cancer. | The importance of this tumor-like lesion is therefore to distinguish it from cancer. As myoepithelial cells are not present in cancer, we can be certain that this slide is a complex sclerosing lesion and not a tumor. Also, the very mild degree of atypia here is not suggestive of cancer. | ||
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''The topic list used to call this “intraductal papilloma”, but that’s wrong. The topic list is corrected as of the spring semester of 2020.'' | ''The topic list used to call this “intraductal papilloma”, but that’s wrong. The topic list is corrected as of the spring semester of 2020.'' | ||
[[Category:Pathology 2 - Histopathology slides]] | [[Category:Pathology 2 - Histopathology slides]] | ||