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25. Subacute granulomatous thyreoiditis (De Quervain): Difference between revisions

25. Subacute granulomatous thyreoiditis (De Quervain) (view source)

Revision as of 14:10, 7 July 2024

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(Created page with "'''Staining''': HE '''Organ''': Thyroid '''Description''': Areas of normal thyroid is separated by fibrosis, causing the formation of “islands” of thyroid follicles. Also present are some giant cells, indicating that this is a granulomatous inflammation. '''Diagnosis''': Subacute granulomatous thyroiditis / de Quervain’s thyroiditis '''Causes''': * Viral infection, often upper respiratory tract '''Theory''': This is a self-limiting disease that goes away af...")
 
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'''Staining''': HE
[[File:Subacute granulomatous thyroiditis - overview.png|thumb|Overview. Already from this magnification can you see that there is fibrosis surrounding small “islands” of thyroid follicles. The bright, left area of the slide is where it is easiest to find giant cells.]]'''Staining''': HE


'''Organ''': Thyroid
'''Organ''': Thyroid
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Areas of normal thyroid is separated by fibrosis, causing the formation of “islands” of thyroid follicles. Also present are some giant cells, indicating that this is a granulomatous inflammation.
Areas of normal thyroid is separated by fibrosis, causing the formation of “islands” of thyroid follicles. Also present are some giant cells, indicating that this is a granulomatous inflammation.


'''Diagnosis''': Subacute granulomatous thyroiditis / de Quervain’s thyroiditis
'''Diagnosis''': Subacute granulomatous thyroiditis / de Quervain’s thyroiditis[[File:Subacute granulomatous thyroiditis - islands.png|thumb|Islands]]'''Causes''':
 
'''Causes''':


* Viral infection, often upper respiratory tract
* Viral infection, often upper respiratory tract
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This is a self-limiting disease that goes away after 6-8 weeks without treatment. Fibrosis is only present in the late stages of this condition, either right before or after remission. This indicates that this sample was taken from a patient who had late-stage subacute granulomatous thyroiditis. This also explains why there are so few giant cells present.
This is a self-limiting disease that goes away after 6-8 weeks without treatment. Fibrosis is only present in the late stages of this condition, either right before or after remission. This indicates that this sample was taken from a patient who had late-stage subacute granulomatous thyroiditis. This also explains why there are so few giant cells present.
[[File:Subacute granulomatous thyroiditis - overview.png|center|thumb|Overview. Already from this magnification can you see that there is fibrosis surrounding small “islands” of thyroid follicles. The bright, left area of the slide is where it is easiest to find giant cells.]]
[[File:Subacute granulomatous thyroiditis - giant cells.png|thumb|Giant cells|left]]
[[File:Subacute granulomatous thyroiditis - islands.png|center|thumb|Islands]]
[[File:Subacute granulomatous thyroiditis - comparison.png|thumb|Comparison between giant cells and thyroid follicles]]
[[File:Subacute granulomatous thyroiditis - giant cells.png|center|thumb|Giant cells]]
[[File:Subacute granulomatous thyroiditis - comparison.png|center|thumb|Comparison between giant cells and thyroid follicles]]
[[Category:Pathology 2 - Histopathology slides]]
[[Category:Pathology 2 - Histopathology slides]]