23. Senile plaques and neurofibrillar degeneration: Difference between revisions

23. Senile plaques and neurofibrillar degeneration (view source)

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 '''Organ''': Brain, hippocampus
-'''Description''':
+'''Description''': The hippocampus is visible and that’s where the characteristic findings are visible on this slide.
-The hippocampus is visible and that’s where the characteristic findings are visible on this slide.
+''Senile plaques'' are extracellular deposits of β-amyloid that are surrounded by silver-positive proteins. The amyloids themselves aren’t stained by silver and are therefore pale. These plaques are therefore visible as large black foci with a pale core. ''Neurofibrillary tangles'' are intracellular bundles of hyperphosphorylated ''tau''. These tangles are stained by silver and causes the neurons to be stained black.
-''Senile plaques'' are extracellular deposits of β-amyloid that are surrounded by silver-positive proteins. The amyloids themselves aren’t stained by silver and are therefore pale. These plaques are therefore visible as large black foci with a pale core.
-''Neurofibrillary tangles'' are intracellular bundles of hyperphosphorylated ''tau''. These tangles are stained by silver and causes the neurons to be stained black.
 '''Diagnosis''': Alzheimer disease (senile plaques, neurofibrillary tangles)[[File:Alzheimer - senile plaques.png|thumb|Senile plaques and amyloid cores]]'''Risk factors:'''