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23. Senile plaques and neurofibrillar degeneration: Difference between revisions

23. Senile plaques and neurofibrillar degeneration (view source)

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(Created page with "'''Staining''': Silver stain (Bielschowsky) '''Organ''': Brain, hippocampus '''Description''': The hippocampus is visible and that’s where the characteristic findings are visible on this slide. ''Senile plaques'' are extracellular deposits of β-amyloid that are surrounded by silver-positive proteins. The amyloids themselves aren’t stained by silver and are therefore pale. These plaques are therefore visible as large black foci with a pale core. ''Neurofibrillar...")
 
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'''Staining''': Silver stain (Bielschowsky)
[[File:Alzheimer - overview.png|thumb|Overview]]'''Staining''': Silver stain (Bielschowsky)


'''Organ''': Brain, hippocampus
'''Organ''': Brain, hippocampus
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''Neurofibrillary tangles'' are intracellular bundles of hyperphosphorylated ''tau''. These tangles are stained by silver and causes the neurons to be stained black.
''Neurofibrillary tangles'' are intracellular bundles of hyperphosphorylated ''tau''. These tangles are stained by silver and causes the neurons to be stained black.


'''Diagnosis''': Alzheimer disease (senile plaques, neurofibrillary tangles)
'''Diagnosis''': Alzheimer disease (senile plaques, neurofibrillary tangles)[[File:Alzheimer - senile plaques.png|thumb|Senile plaques and amyloid cores]]'''Risk factors:'''
 
'''Risk factors:'''


* Genetic factors
* Genetic factors
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This slide is overstained, so the characteristic findings are therefore hard to distinguish from background noise.
This slide is overstained, so the characteristic findings are therefore hard to distinguish from background noise.
[[File:Alzheimer - overview.png|center|thumb|Overview]]
[[File:Alzheimer - NFTs.png|thumb|These nerve cell bodies are stained black as they contain neurofibrillary tangles]]
[[File:Alzheimer - senile plaques.png|center|thumb|Senile plaques and amyloid cores]]
[[File:Alzheimer - NFTs.png|center|thumb|These nerve cell bodies are stained black as they contain neurofibrillary tangles]]
[[Category:Pathology 2 - Histopathology slides]]
[[Category:Pathology 2 - Histopathology slides]]