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22. Glioblastoma: Difference between revisions

22. Glioblastoma (view source)

Revision as of 14:06, 7 July 2024

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(Created page with "'''Staining''': HE '''Organ''': Brain '''Description''': There are four important characteristics in glioblastomas: * Severe atypia * Many mitotic figures * Pseudopalisading necrosis * Microvascular proliferation Microvascular proliferation is a phenomenon where the tumor contains small capillaries who are irregular and are comprised of atypical endothelial cells. Pseudopalisading necrosis is a phenomenon where the tumor contains areas of necrosis, and this necrosi...")
 
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'''Staining''': HE
[[File:Glioblastoma - Overview.png|thumb|Overview|362x362px]]'''Staining''': HE


'''Organ''': Brain
'''Organ''': Brain
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Pseudopalisading necrosis is a phenomenon where the tumor contains areas of necrosis, and this necrosis is surrounded by hypercellular regions.
Pseudopalisading necrosis is a phenomenon where the tumor contains areas of necrosis, and this necrosis is surrounded by hypercellular regions.


'''Diagnosis''': Glioblastoma
'''Diagnosis''': Glioblastoma[[File:Glioblastoma - pseudopalisading necrosis.png|thumb|Pseudopalisading necrosis. The hypercellular regions form a “fence” around the necrosis.|329x329px]]'''Risk factors:'''
 
'''Risk factors:'''


* Age 50 – 70
* Age 50 – 70
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Glioblastoma is a grade IV astrocytic tumor that is defined histologically be the four characteristics described above. It must be differentiated from ''anaplastic astrocytoma'', a grade III astrocytic tumor. Anaplastic astrocytoma also shows severe atypia and many mitotic figures but no pseudopalisading necrosis or microvascular proliferation.
Glioblastoma is a grade IV astrocytic tumor that is defined histologically be the four characteristics described above. It must be differentiated from ''anaplastic astrocytoma'', a grade III astrocytic tumor. Anaplastic astrocytoma also shows severe atypia and many mitotic figures but no pseudopalisading necrosis or microvascular proliferation.
[[File:Glioblastoma - Overview.png|center|thumb|Overview]]
[[File:Glioblastoma - atypia.png|thumb|Tumor cells show severe atypia and there are many mitotic figures present.|left|364x364px]]
[[File:Glioblastoma - pseudopalisading necrosis.png|center|thumb|Pseudopalisading necrosis. The hypercellular regions form a “fence” around the necrosis.]]
[[File:Glioblastoma - microvascular proliferation.png|thumb|Tumor on the left, showing microvascular proliferation. Normal brain parenchyme on the right for comparison.|346x346px]]
[[File:Glioblastoma - atypia.png|center|thumb|Tumor cells show severe atypia and there are many mitotic figures present.]]
[[File:Glioblastoma - microvascular proliferation.png|center|thumb|Tumor on the left, showing microvascular proliferation. Normal brain parenchyme on the right for comparison.]]
[[Category:Pathology 2 - Histopathology slides]]
[[Category:Pathology 2 - Histopathology slides]]