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16. Follicular lymphoma: Difference between revisions

16. Follicular lymphoma (view source)

Revision as of 13:45, 7 July 2024

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'''Diagnosis''': Follicular lymphoma
'''Diagnosis''': Follicular lymphoma


'''Causes''': t(14;18) translocation – fusion of BCL2 and IgH genes[[File:Follicular lymphoma - compression.png|thumb|The area between the neoplastic follicles is compressed]]'''Theory''': The translocation of the IgH gene (with its highly active promoter region) into the BCL2 (an antiapoptotic protein) on chromosome 18 causes the BCL2 gene to be overexpressed. These cells therefore have high antiapoptotic activity. Due to this is there no apoptosis in the follicles, so the “starry sky” pattern not visible.[[File:Follicular lymphoma - comparison with physiology.jpg|thumb|Left: Physiological follicular hyperplasia. Right: Follicular lymphoma. The slides are not at the same magnification. The follicles in follicular lymphoma have less prominent and more incomplete mantle zones. Compare the “starry sky” pattern.|none]]
'''Causes''': t(14;18) translocation – fusion of BCL2 and IgH[[File:Follicular lymphoma - compression.png|thumb|The area between the neoplastic follicles is compressed]]'''Theory''': The translocation of the IgH gene (with its highly active promoter region) into the BCL2 (an antiapoptotic protein) on chromosome 18 causes the BCL2 gene to be overexpressed. These cells therefore have high antiapoptotic activity. Due to this is there no apoptosis in the follicles, so the “starry sky” pattern not visible.[[File:Follicular lymphoma - comparison with physiology.jpg|thumb|Left: Physiological follicular hyperplasia. Right: Follicular lymphoma. The slides are not at the same magnification. The follicles in follicular lymphoma have less prominent and more incomplete mantle zones. Compare the “starry sky” pattern.|none]]
[[File:Follicular lymphoma - pleomorphism.png|thumb|The tumor cells show only mild atypia. This is taken from a neoplastic follicle.|none]]
[[File:Follicular lymphoma - pleomorphism.png|thumb|The tumor cells show only mild atypia. This is taken from a neoplastic follicle.|none]]
[[Category:Pathology 2 - Histopathology slides]]
[[Category:Pathology 2 - Histopathology slides]]