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12. Kimmelstiel Wilson syndrome: Difference between revisions
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(Created page with "'''Staining''': PAS-H '''Organ''': Kidney '''Description''': Even with low magnification are PAS-positive glomeruli visible. With higher magnification are PAS-positive nodules inside the glomeruli visible. '''Diagnosis''': Nodular glomerulosclerosis '''Causes''': * Diabetes '''Theory''': Nodular glomerulosclerosis is the third and last stage of diabetic nephropathy. It occurs as a result of glucose combining with proteins in the glomerular vessel wall to form ''A...") |
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'''Staining''': PAS-H | [[File:Kimmestiel Wilson syndrome - overview.png|thumb|Overview]]'''Staining''': PAS-H | ||
'''Organ''': Kidney | '''Organ''': Kidney | ||
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* Diabetes | * Diabetes | ||
'''Theory''': | '''Theory''':[[File:Kimmestiel Wilson syndrome - nodules.png|thumb|Nodules]]Nodular glomerulosclerosis is the third and last stage of diabetic nephropathy. It occurs as a result of glucose combining with proteins in the glomerular vessel wall to form ''AGE'' products. AGEs stimulate the mesangial cells to produce more mesangial matrix, which is what forms the PAS positive nodules. The nodules are called Kiemmelstiel-Wilson nodules or lesions. | ||
Nodular glomerulosclerosis is the third and last stage of diabetic nephropathy. It occurs as a result of glucose combining with proteins in the glomerular vessel wall to form ''AGE'' products. AGEs stimulate the mesangial cells to produce more mesangial matrix, which is what forms the PAS positive nodules. The nodules are called Kiemmelstiel-Wilson nodules or lesions. | |||
[[Category:Pathology 2 - Histopathology slides]] | [[Category:Pathology 2 - Histopathology slides]] | ||