Jump to content

7. HBs antigen positivism (Shikata orcein): Difference between revisions

no edit summary
(Created page with "'''Staining''': Shikata orcein '''Organ''': Liver '''Description''': The liver parenchyme in this slide has been divided into “pseudolobules”. These pseudolobules don’t correspond to the normal liver lobules and have wildly varying sizes. The pseudolobules are surrounded by scar tissue. In two of the pseudolobules there are hepatocytes which are HBsAG positive. Their morphology is called “ground-glass hepatocytes”. '''Diagnosis''': HBs antigen positive chr...")
 
No edit summary
 
Line 1: Line 1:
'''Staining''': Shikata orcein
[[File:HBs antigen positivity - overview.png|thumb|Overview|360x360px]]'''Staining''': Shikata orcein


'''Organ''': Liver
'''Organ''': Liver
Line 14: Line 14:


* Hepatitis B infection
* Hepatitis B infection
 
[[File:HBs antigen positivity - hepatocytes.png|thumb|This shows the HBsAg positive hepatocytes|365x365px]]'''Theory''':
'''Theory''':


Normal orcein stains elastic fibres while Shikata orcein stains the hepatitis B surface antigen (HBsAg) as well. This staining is not used in clinical practice as serology is preferred instead.
Normal orcein stains elastic fibres while Shikata orcein stains the hepatitis B surface antigen (HBsAg) as well. This staining is not used in clinical practice as serology is preferred instead.
Line 22: Line 21:


The extensive pseudolobule formation with scar tissue surrounding them is characteristic for fully mature cirrhosis.
The extensive pseudolobule formation with scar tissue surrounding them is characteristic for fully mature cirrhosis.
[[File:HBs antigen positivity - overview.png|center|thumb|Overview]]
[[File:HBs antigen positivity - hepatocytes.png|center|thumb|This shows the HBsAg positive hepatocytes]]
[[Category:Pathology 2 - Histopathology slides]]
[[Category:Pathology 2 - Histopathology slides]]