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48. Silicosis: Difference between revisions

48. Silicosis (view source)

Revision as of 12:48, 5 July 2024

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(Created page with "'''Staining''': HE '''Organ''': Lung '''Description''': The lung parenchyme is normal, however some large nodules can be seen. These nodules have two zones, the peripheral zone and central zone. Anthracosis is also present. The peripheral zone contains macrophages and fibroblasts. The central zone contains scar tissue and no cells. '''Diagnosis''': Silicosis '''Causes''': * Silica dust inhalation '''Theory''': The central zone contains no cells, so it can be mi...")
 
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'''Staining''': HE
[[File:Silicosis overview.png|thumb|Overview of the slide|371x371px]]'''Staining''': HE


'''Organ''': Lung
'''Organ''': Lung
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The lung parenchyme is normal, however some large nodules can be seen. These nodules have two zones, the peripheral zone and central zone. Anthracosis is also present.
The lung parenchyme is normal, however some large nodules can be seen. These nodules have two zones, the peripheral zone and central zone. Anthracosis is also present.


The peripheral zone contains macrophages and fibroblasts.
The peripheral zone contains macrophages and fibroblasts. The central zone contains scar tissue and no cells.
 
The central zone contains scar tissue and no cells.


'''Diagnosis''': Silicosis
'''Diagnosis''': Silicosis
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The central zone contains no cells, so it can be mistaken for necrosis. Compare these silicotic nodules to the necrotic granulomas in miliary tuberculosis and don’t mix them!
The central zone contains no cells, so it can be mistaken for necrosis. Compare these silicotic nodules to the necrotic granulomas in miliary tuberculosis and don’t mix them!
[[File:Silicosis overview.png|center|thumb|Overview of the slide]]
[[File:Silicosis silicotic nodule.png|thumb|Close-up of a silicotic nodule|left]]
[[File:Silicosis silicotic nodule.png|center|thumb|Close-up of a silicotic nodule]]
[[File:Silicosis peripheral zone.png|thumb|From the peripheral zone]]
[[File:Silicosis peripheral zone.png|center|thumb|From the peripheral zone]]
[[File:Silicosis central zone.png|thumb|From the central zone. No cells, just scar tissue|left]]
[[File:Silicosis central zone.png|center|thumb|From the central zone. No cells, just scar tissue]]
[[Category:Pathology 1 - Histopathology slides]]
[[Category:Pathology 1 - Histopathology slides]]