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8. Steatosis hepatis: Difference between revisions

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(Created page with "'''Staining''': HE and oil-red '''Organ''': Liver '''Description''': HE: We can see the portal triad, meaning that we are looking at a liver. There is panlobular fat accumulation (fat is present in the whole lobule) in the whole slide. Oil-red: With this staining the fat is reddish-orangeish. '''Diagnosis''': Hepatic steatosis Causes: * Alcohol consumption * Metabolic syndrome (DM2, obesity) * Medications '''Theory''': When fixating the normal slides, we use for...")
 
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'''Staining''': HE and oil-red
[[File:Hepatic steatosis HE overview.jpg|thumb|Overview of HE]]'''Staining''': HE and oil-red


'''Organ''': Liver
'''Organ''': Liver
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* Alcohol consumption
* Alcohol consumption
* Metabolic syndrome (DM2, obesity)
* Metabolic syndrome (DM2, obesity)
* Medications
* Medications[[File:Hepatic steatosis oil red overview.jpg|thumb|Overview of oil red]]


'''Theory''':
'''Theory''':
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The enzyme ADH that metabolizes ethanol depletes NAD+ and increases NADH. NADH stimulates fatty acid synthesis. NAD+ is needed for β-oxidation of the fat. This causes fat to accumulate in the hepatocytes.
The enzyme ADH that metabolizes ethanol depletes NAD+ and increases NADH. NADH stimulates fatty acid synthesis. NAD+ is needed for β-oxidation of the fat. This causes fat to accumulate in the hepatocytes.
[[File:Hepatic steatosis HE overview.jpg|center|thumb|Overview of HE]]
[[File:Hepatic steatosis HE portal triad.jpg|thumb|A portal triad, with the artery, bile duct and vein in that order, clockwise.|left]]
[[File:Hepatic steatosis oil red overview.jpg|center|thumb|Overview of oil red]]
[[File:Hepatic steatosis HE portal triad.jpg|center|thumb|A portal triad, with the artery, bile duct and vein in that order, clockwise.]]
[[File:Hepatic steatosis HE panlobar fat.jpg|center|thumb|Panlobular fat accumulation.]]
[[File:Hepatic steatosis HE panlobar fat.jpg|center|thumb|Panlobular fat accumulation.]]
[[File:Hepatic steatosis HE bile.jpg|center|thumb|Bile between cells.]]
[[File:Hepatic steatosis HE bile.jpg|thumb|Bile between cells.|left]]
[[File:Hepatic steatosis oil red fat.jpg|center|thumb|Fat in hepatocytes as seen in oil-red staining. The big orange blobs are fat.]]
[[File:Hepatic steatosis oil red fat.jpg|center|thumb|Fat in hepatocytes as seen in oil-red staining. The big orange blobs are fat.]]
[[Category:Pathology 1 - Histopathology slides]]
[[Category:Pathology 1 - Histopathology slides]]