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11. Haemochromatosis: Difference between revisions
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(Created page with "'''Organ''': Liver, small intestine, kidney '''Description''': We can see a slice of liver in the front, a piece of small intestine behind it, and a kidney in the bottom. The organs are blue or bluish. The liver is especially blue. '''Diagnosis''': Haemochromatosis '''Causes''': * For primary haemochromatosis: ** HFE-gene missense mutation * For secondary haemochromatosis: ** Haemolysis (autoimmune hemolytic anaemia) ** Repeated blood transfusions ** Massively incre...") |
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** Decreased iron utilization | ** Decreased iron utilization | ||
'''Theory''': | '''Theory''':[[File:Haemochromatosis preparation.png|thumb|Haemochromatosis preparation]]In hemosiderosis the hemosiderin pigment is accumulating in cells but there is no tissue damage. In haemochromatosis however, the pigment is accumulating ''and'' there is tissue damage. | ||
In hemosiderosis the hemosiderin pigment is accumulating in cells but there is no tissue damage. In haemochromatosis however, the pigment is accumulating ''and'' there is tissue damage. | |||
These preparations are not stored in formalin but in Prussian blue, a stain that stains iron blue. The liver, being a metabolic organ, is logically the bluest. However, since hemochromatosis is a systemic process, all organs are filled with iron to some extent, which is why the kidney and small intestine are also stained blue. | These preparations are not stored in formalin but in Prussian blue, a stain that stains iron blue. The liver, being a metabolic organ, is logically the bluest. However, since hemochromatosis is a systemic process, all organs are filled with iron to some extent, which is why the kidney and small intestine are also stained blue. | ||
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Diabetes occurs because of the damage of the pancreatic islets due to the hemosiderin and the skin is discoloured because of hemosiderin in the skin. | Diabetes occurs because of the damage of the pancreatic islets due to the hemosiderin and the skin is discoloured because of hemosiderin in the skin. | ||
[[Category:Pathology 1 - Macropreparations]] | [[Category:Pathology 1 - Macropreparations]] | ||