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Cholestasis: Difference between revisions
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(Created page with "'''Cholestasis''' refers to reduced or blocked flow of bile through the biliary tree, usually due to an obstruction. This causes bile components, including bile acids and bilirubin to be absorbed into the blood. It may cause jaundice if severe enough. Cholestasis may be '''intrahepatic''' or '''extrahepatic''', depending on the location of the problem. Treatment depends on the underlying cause and is indicated as cholestasis predisposes to secondary infection (ch...") |
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== Diagnosis and evaluation == | == Diagnosis and evaluation == | ||
''See also [[liver biochemical tests]].'' | |||
Laboratory evaluation can show signs of cholestasis, mostly the ''cholestatic parametres'' ALP and GGT. Alkaline phosphatase (ALP) is significantly elevated, more than three times the upper normal limit, but ALP can be elevated in bone disorders as well. Gamma-glutamyl transpeptidase (GGT) is also significantly elevated in cholestasis. If ALP and not GGT is elevated, a non-biliary cause is likely. | Laboratory evaluation can show signs of cholestasis, mostly the ''cholestatic parametres'' ALP and GGT. Alkaline phosphatase (ALP) is significantly elevated, more than three times the upper normal limit, but ALP can be elevated in bone disorders as well. Gamma-glutamyl transpeptidase (GGT) is also significantly elevated in cholestasis. If ALP and not GGT is elevated, a non-biliary cause is likely. | ||