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Low-molecular-weight heparin: Difference between revisions
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(Created page with "<section begin="clinical biochemistry" />The '''low-molecular-weight heparins''' (LMWH) are ''fractionated heparins'' as opposed to unfractionated heparin. These drugs are just fragments of the unfractionated heparin. They’re more predictable and have longer half-life than unfractionated heparin and are therefore preferred in most cases.<section end="clinical biochemistry" /> The LMWHs have a molecular weight of 3 – 4 kDa. == Compounds == * Enoxaparin (Clexane...") |
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<section begin="clinical biochemistry" />The '''low-molecular-weight heparins''' (LMWH) are ''fractionated heparins'' as opposed to [[unfractionated heparin]]. These drugs are just fragments of the unfractionated heparin. They’re more predictable and have longer half-life than unfractionated heparin and are therefore preferred in most cases.<section end="clinical biochemistry" /> | <section begin="clinical biochemistry" />The '''low-molecular-weight heparins''' (LMWH) are commonly used [[anticoagulants]]. They are ''fractionated heparins'' as opposed to [[unfractionated heparin]]. These drugs are just fragments of the unfractionated heparin. They’re more predictable and have longer half-life than unfractionated heparin and are therefore preferred in most cases.<section end="clinical biochemistry" /> | ||
The LMWHs have a molecular weight of 3 – 4 kDa. | The LMWHs have a molecular weight of 3 – 4 kDa. | ||
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== Monitoring == | == Monitoring == | ||
<section begin="clinical biochemistry" />There is no need to monitor the effect of LMWH, as the anticoagulant effect is much more predictable based on the dose than for UFH and [[warfarin]]. One can measure anti-factor Xa activity, but there is no established therapeutic range anyway. <section end="clinical biochemistry" /> | <section begin="clinical biochemistry" />There is no need to monitor the effect of LMWH, as the anticoagulant effect is much more predictable based on the dose than for UFH and [[warfarin]]. One can measure anti-factor Xa activity, but there is no established therapeutic range anyway. <section end="clinical biochemistry" /> | ||
<noinclude>[[Category:Pharmacology]]</noinclude> | <noinclude> | ||
[[Category:Pharmacology]] | |||
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