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Cholangiocellular carcinoma: Difference between revisions
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(Created page with "Cholangiocellular carcinoma (CCC), also called cholangiocarcinoma, is a malignancy of the cholangiocytes that line the bile ducts. It can occur in the extrahepatic or intrahepatic bile ducts, with the former being more common. It can also occur in the gallbladder. If a CCC occurs at the confluence of the right and left hepatic bile ducts, it’s known as a Klatskin tumor. It's an aggressive malignancy with a poor prognosis. == Clinical features == Extrahepatic cholangi...") |
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Cholangiocellular carcinoma (CCC), also called cholangiocarcinoma, is a malignancy of the cholangiocytes that line the bile ducts. It can occur in the extrahepatic or intrahepatic bile ducts, with the former being more common. It can also occur in the gallbladder. If a CCC occurs at the confluence of the right and left hepatic bile ducts, it’s known as a Klatskin tumor. | '''Cholangiocellular carcinoma''' (CCC), also called '''cholangiocarcinoma''', is a malignancy of the cholangiocytes that line the bile ducts and gallbladder. It can occur in the extrahepatic or intrahepatic bile ducts, with the former being more common. It can also occur in the gallbladder. If a CCC occurs at the confluence of the right and left hepatic bile ducts, it’s known as a Klatskin tumor. | ||
It's an aggressive malignancy with a poor prognosis. | It's an aggressive malignancy with a poor prognosis. | ||
== Clinical features == | == Clinical features == | ||
Extrahepatic cholangiocarcinoma presents with signs of cholestasis, including jaundice, pale stool, dark urine, and pruritus. Courvoisier sign (palpable nontender gallbladder) is typical. Intrahepatic CCC and gallbladder cancer is more likely to be asymptomatic and present later. | Extrahepatic cholangiocarcinoma presents with signs of [[cholestasis]], including [[jaundice]], pale stool, dark urine, and pruritus. [[Courvoisier sign]] (palpable nontender gallbladder) is typical. Intrahepatic CCC and gallbladder cancer is more likely to be asymptomatic and present later. | ||
== Diagnosis and evaluation == | == Diagnosis and evaluation == | ||