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(Created page with "'''Thalassaemia''' is a group of diseases characterised by one or more defective globin genes, causing haemolytic anaemia. Like sickle cell anaemia it is more common in Africa and the Mediterranean, but also south-east Asia. == Pathophysiology == We distinguish alpha and beta thalassaemia, based on whether the alpha or beta globin genes are defective. Alpha globin chain production is controlled by two genes, so there are four alleles that can...") |
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