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48. Hypertrophic cardiomyopathy: Difference between revisions

48. Hypertrophic cardiomyopathy (view source)

Revision as of 18:42, 29 November 2022

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(Created page with "'''Organ''': Heart '''Description''': Two sections of a heart can be seen. On both section, but especially on the right, is it obvious that the septum is severely thickened, to the point where it bulges into the left ventricle. The left ventricle ends up with a banana-shaped lumen. '''Diagnosis''': Obstructive type of hypertrophic cardiomyopathy '''Causes''': * Genetic mutations '''Theory''': In hypertrophic cardiomyopathy is the heart as a whole hypertrophied, ho...")
 
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'''Description''':
'''Description''':


Two sections of a heart can be seen. On both section, but especially on the right, is it obvious that the septum is severely thickened, to the point where it bulges into the left ventricle. The left ventricle ends up with a banana-shaped lumen.
Two heart sections can be seen (from separate hearts). On both sections, but especially on the right, the septum is severely thickened, to the point where it bulges into the left ventricle. The left ventricle ends up with a banana-shaped lumen.


'''Diagnosis''': Obstructive type of hypertrophic cardiomyopathy
'''Diagnosis''': Obstructive type of hypertrophic cardiomyopathy
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In hypertrophic cardiomyopathy is the heart as a whole hypertrophied, however the septum is 3x as hypertrophied as the rest. This causes the septum to become severely thickened and bulge into the left ventricle.
In hypertrophic cardiomyopathy is the heart as a whole hypertrophied, however the septum is 3x as hypertrophied as the rest. This causes the septum to become severely thickened and bulge into the left ventricle.


In 1/3 of hypertrophic cardiomyopathies are of the obstructive type, where the septum can completely compress the aorta, which causes the blood pressure to drop so significantly that syncope occurs. This only happens occasionally, but sudden syncope is a characteristic finding in patients with obstructive hypertrophic cardiomyopathy.
1/3 of hypertrophic cardiomyopathies are of the obstructive type, where the septum can suddenly (and reversibly) obstruct the left ventricular outflow tract (LVOT), which causes the blood pressure to drop so significantly that syncope occurs. The obstruction is transient and reversible. Sudden syncope is a characteristic finding in patients with obstructive hypertrophic cardiomyopathy. The obstruction most likely occurs due to negative pressure forming in the LVOT, which pulls the mitral valve toward the septum. This is called ''systolic anterior motion'' and is due to the ''Venturi effect'' (not important to know the exact mechanism).
[[File:Hypertrophic cardiomyopathy prep.png|center|thumb|Hypertrophic cardiomyopathy prep]]
[[File:Hypertrophic cardiomyopathy prep.png|center|thumb|Hypertrophic cardiomyopathy prep]]
[[Category:Pathology 1 - Macropreparations]]
[[Category:Pathology 1 - Macropreparations]]