Nikolas
Created page with "'''Polycythaemia vera''' (PV) is an MPN characterised by ''trilinear proliferation,'' i.e. growth of erythroid, granulocytic, and megakaryocytic cell lines, causing elevation of all three types of blood cells in the blood. It’s caused by an acquired gain-of-function mutation in the JAK2 gene which makes myeloid cells proliferate independently of the hormone EPO. == Clinical features == Despite an increased blood cell mass, most people a..."
