Nikolas
Created page with "Ischaemia reduces the oxygen supply to cells. This causes them to switch to anaerobic metabolism, which produces much less ATP. The Na+/K+ ATPase dysfunctions, causing Na+ to enter the cell. As a result Ca2+ also enters. Intracellular calcium damages the mitochondria and activates many destructive enzymes. Damaged mitochondria produce more reactive oxygen species, especially during reperfusion. == Ischaemia == One of the major consequences of shock is that the tissues d..."