Fibrin

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Fibrin is a protein involved in the coagulation cascade. Its inactive form fibrinogen is converted to fibrin by thrombin in the last steps of the coagulation cascade. Fibrinogen is synthesised in the liver and is an acute phase protein.

Fibrinogen in laboratory medicine

Fibrinogen can be measured in the plasma in the evaluation of disseminated intravascular coagulation (DIC), bleeding disorders, and to monitor fibrinolytic therapy.