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  • 08:11, 25 January 2023 Nikolas talk contribs created page 8. Primary B-cell development (Created page with "The primary B-cell development ends with a mature B-cell and takes place in the bone marrow and lymphoid tissues, while the secondary B-cell development takes place when the B-cell binds an antigen in a lymph node. Only 5% of the cells that begin primary B-cell development will finish it, the rest will die. == Development == B-cells develop from hematopoietic stem cells (HSCs) in the bone marrow. If the <abbr>HSC</abbr> expresses low levels of a protein called PU1, it w...") Tag: Visual edit