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- 10:57, 5 May 2022 Nikolas talk contribs created page 63. Chronic restrictive lung diseases (Created page with "== Introduction == Diseases that affect the lung interstitium usually cause reduced compliance (increased stiffness) of the lung. This increases the work of breathing, leading to dyspnoea. Several parts of the interstitium is involved in gas exchange, like the alveolar epithelium and vessels, so diseases of the interstitium affect the gas exchange as well, causing V/Q mismatches and therefore possibly respiratory failure. Pulmonary hypertension occurs because the whole...") Tag: Visual edit