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  • 09:00, 23 April 2023 Nikolas talk contribs created page 55. Opioid analgesic drugs. Morphine and codeine (Created page with "== Nociception == The main type of peripheral sensory neuron that mediates pain is the ''polymodal nociceptor'' (PMN). This is non-myelinated C-type fibre that responds to thermal, mechanical and chemical stimuli. The chemical stimuli that act on PMNs include bradykinin, protons and vanilloids like capsaicin, which is what makes spicy food spicy. The sensitivity of PMNs is increased by prostaglandins, which explains the hyperalgesia that occurs during inflammation. The...") Tag: Visual edit