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  • 10:46, 2 March 2023 Nikolas talk contribs created page 48. Pathobiochemistry of the late complications of diabetes mellitus (Created page with "As explained in the previous topic are these four factors important in the development of microvascular disease in diabetes mellitus. == Pseudohypoxia == As already explained will hyperglycaemia increase the activity of the polyol pathway, which depletes NADPH and increases the NADH/NAD+ ratio. The latter causes a metabolic state of cells that is similar to hypoxia, called pseudohypoxia. The affected cells produce less ATP and more free radicals. Also, the amount of gly...") Tag: Visual edit