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  • 22:24, 7 May 2022 Nikolas talk contribs created page 46. Tumour suppressor genes II. NF1, NF2, VHL, WT-1 and WT-2. Related syndromes (Created page with "== NF1 == NF1 is a gene that codes for a protein called ''neurofibromin.'' The physiological function of this protein is to stimulate the GTPase activity of Ras, inhibiting it. Mutations in the gene are associated with neurofibromatosis type 1, a disease with many symptoms. The mutation causes tumors to form along the nervous system that can form anywhere in the body. Diagnosis of the disease requires two or more of the following criteria: * Brownish spots on the body,...") Tag: Visual edit