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• 08:24, 25 January 2023 Nikolas talk contribs created page 12. B-cell affinity maturation and isotype switching (Created page with "== Affinity maturation == thumb|366x366px|Illustration of how changing the variable domain on an antibody can change the shape of the antigen-binding site and thereby increase its affinity for the antigen As written in the last topic, the follicular B-cells in the germinal center undergo a process called ''affinity maturation''. This causes the B-cells to produce antibodies with higher affinity to the antigen than originally. During the...") Tag: Visual edit