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- 08:22, 25 January 2023 Nikolas talk contribs created page 11. Extrafollicular and germinal centre reactions (Created page with "== B-cell subsets and their characteristics == === B1 B-cells === The B1 type B-cells are, like the γδ T-cells, made only during the embryonic life. Instead of dying out after that however, they renew themselves in our body, outside of lymphoid organs, in the periphery. The presence of a spleen is essential in the survival of the B1 B-cells. They produce low-affinity antibodies and sometimes even antibodies that can bind to self-antigens (antigens of proteins that are...") Tag: Visual edit