30. Phaeochromocytoma

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Revision as of 19:01, 15 November 2022 by Nikolas (talk | contribs) (Created page with "'''Staining''': HE '''Organ''': Adrenal gland '''Description''': The whole slide is tumor except for a small part on the lower right side, where we can see normal adrenal cortex. The tumor cells show mild atypia and have eosinophilic cytoplasm and produce a pattern called “zellballen”, which looks like small nests. The nests are separated by a vascular network. The cells that seperate the zellballen are called sustentacular (supporting) cells. '''Diagnosis''': P...")
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Staining: HE

Organ: Adrenal gland

Description:

The whole slide is tumor except for a small part on the lower right side, where we can see normal adrenal cortex.

The tumor cells show mild atypia and have eosinophilic cytoplasm and produce a pattern called “zellballen”, which looks like small nests. The nests are separated by a vascular network. The cells that seperate the zellballen are called sustentacular (supporting) cells.

Diagnosis: Phaeochromocytoma

Risk factors:

  • Germ-line mutations in RET, NF1, VHL

Theory:

These tumors produce catecholamines sporadically, causing paroxysmal hypertensive crises.

Overview
Border
Tumour cells
Zellballen (cell balls) pattern