18. Diffuse large B-cell lymphoma (DLBCL)

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Revision as of 21:25, 3 November 2022 by Nikolas (talk | contribs) (Created page with "'''Staining''': HE and PAS '''Organ''': Lymph node (not recognizable) '''Description''': No healthy lymph node tissue is visible. The tumor cells form no structures (like glands or nests). The cells are large and show severe atypia/pleiomorphism, almost anaplastic. The cells resemble centroblasts and are therefore said to be centroblastic in appearance or ''centroblastoid.'' There is high mitotic activity (many mitotic figures). On PAS staining are PAS-positive inclu...")
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Staining: HE and PAS

Organ: Lymph node (not recognizable)

Description:

No healthy lymph node tissue is visible. The tumor cells form no structures (like glands or nests). The cells are large and show severe atypia/pleiomorphism, almost anaplastic. The cells resemble centroblasts and are therefore said to be centroblastic in appearance or centroblastoid. There is high mitotic activity (many mitotic figures).

On PAS staining are PAS-positive inclusion bodies in the cytoplasm and nuclei visible, so called Russell bodies and Dutcher bodies, respectively. These inclusion bodies are comprised of immunoglobulin.

Diagnosis: Diffuse large B-cell lymphoma.

Causes:

  • Primary type: mutations in
    • Myc
    • BCL2
    • BCL6
  • Secondary type: Richter transformation from CLL, MZL or FL

Theory:

Necrosis is also a common histological finding in DLBCL but it can’t be seen here.

Overview
The tumor cells form no structures. HE on the left and PAS on the right.
Look at this