48. Silicosis

From greek.doctor
Revision as of 20:29, 19 May 2022 by Nikolas (talk | contribs) (Created page with "'''Staining''': HE '''Organ''': Lung '''Description''': The lung parenchyme is normal, however some large nodules can be seen. These nodules have two zones, the peripheral zone and central zone. Anthracosis is also present. The peripheral zone contains macrophages and fibroblasts. The central zone contains scar tissue and no cells. '''Diagnosis''': Silicosis '''Causes''': * Silica dust inhalation '''Theory''': The central zone contains no cells, so it can be mi...")
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)

Staining: HE

Organ: Lung

Description:

The lung parenchyme is normal, however some large nodules can be seen. These nodules have two zones, the peripheral zone and central zone. Anthracosis is also present.

The peripheral zone contains macrophages and fibroblasts.

The central zone contains scar tissue and no cells.

Diagnosis: Silicosis

Causes:

  • Silica dust inhalation

Theory:

The central zone contains no cells, so it can be mistaken for necrosis. Compare these silicotic nodules to the necrotic granulomas in miliary tuberculosis and don’t mix them!

Overview of the slide
Close-up of a silicotic nodule
From the peripheral zone
From the central zone. No cells, just scar tissue