Therapeutic drug monitoring

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= measurement of drug concentration or activity in plasma

  • Methods
    • High performance liquid chromatography
    • Immunoassay
  • Indications
    • Non-linear kinetics of drug
    • When there is poor compliance
    • If the therapeutic effect can’t be assessed clinically
    • If the therapeutic index is low
      • Warfarin
      • Aminoglycosides
      • Antipsychotics
      • Digoxin
      • Lithium
    • When there are signs of overdose
    • To determine pharmacokinetic interactions