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• 21:23, 7 May 2022 Nikolas talk contribs created page 45. Tumour suppressor genes I. RB and p53. Their role in tumorigenesis. Organ examples (Created page with "Tumour suppressors are the genes that code for the proteins that create the checkpoints in the cell cycle, and their protein products. They work as brakes in the cell proliferation. The G1-S checkpoint checks the DNA for damage while the G2-M checkpoint quality checks the DNA after replication and determines whether it’s safe for the cell to divide. When cells sense DNA damage will the cell cycle stop at the checkpoint until the DNA is repaired, or the cell decides tha...") Tag: Visual edit