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  • 16:17, 7 February 2023 Nikolas talk contribs created page 17. Tissue hypoxia, ischemia, reperfusion and tissue metabolism (Created page with "Ischaemia reduces the oxygen supply to cells. This causes them to switch to anaerobic metabolism, which produces much less ATP. The Na+/K+ ATPase dysfunctions, causing Na+ to enter the cell. As a result Ca2+ also enters. Intracellular calcium damages the mitochondria and activates many destructive enzymes. Damaged mitochondria produce more reactive oxygen species, especially during reperfusion. == Ischaemia == One of the major consequences of shock is that the tissues d...") Tag: Visual edit