30. Phaeochromocytoma: Difference between revisions
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[[File:Phaeochromocytoma - overview.png|thumb|Overview]]'''Staining''': HE | [[File:Phaeochromocytoma - overview.png|thumb|Overview|274x274px]]'''Staining''': HE | ||
'''Organ''': Adrenal gland | '''Organ''': Adrenal gland | ||
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The tumor cells show mild atypia and have eosinophilic cytoplasm and produce a pattern called “zellballen”, which looks like small nests. The nests are separated by a vascular network. The cells that seperate the zellballen are called sustentacular (supporting) cells. | The tumor cells show mild atypia and have eosinophilic cytoplasm and produce a pattern called “zellballen”, which looks like small nests. The nests are separated by a vascular network. The cells that seperate the zellballen are called sustentacular (supporting) cells. | ||
'''Diagnosis''': Phaeochromocytoma[[File:Phaeochromocytoma - border.png|thumb|Border]]'''Risk factors:''' | '''Diagnosis''': Phaeochromocytoma[[File:Phaeochromocytoma - border.png|thumb|Border|251x251px]]'''Risk factors:''' | ||
* Germ-line mutations in RET, NF1, VHL | * Germ-line mutations in RET, NF1, VHL | ||
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These tumors produce catecholamines sporadically, causing paroxysmal hypertensive crises. | These tumors produce catecholamines sporadically, causing paroxysmal hypertensive crises. | ||
[[File:Phaeochromocytoma - tumour.png|thumb|Tumour cells|left]] | [[File:Phaeochromocytoma - tumour.png|thumb|Tumour cells|left]] | ||
[[File:Phaeochromocytoma - zellballs.png|thumb|Zellballen (cell balls) pattern]] | [[File:Phaeochromocytoma - zellballs.png|thumb|Zellballen (cell balls) pattern|268x268px]] | ||
[[Category:Pathology 2 - Histopathology slides]] | [[Category:Pathology 2 - Histopathology slides]] | ||
Latest revision as of 15:17, 7 July 2024
Staining: HE
Organ: Adrenal gland
Description:
The whole slide is tumor except for a small part on the lower right side, where we can see normal adrenal cortex.
The tumor cells show mild atypia and have eosinophilic cytoplasm and produce a pattern called “zellballen”, which looks like small nests. The nests are separated by a vascular network. The cells that seperate the zellballen are called sustentacular (supporting) cells.
Diagnosis: Phaeochromocytoma
Risk factors:
- Germ-line mutations in RET, NF1, VHL
Theory:
These tumors produce catecholamines sporadically, causing paroxysmal hypertensive crises.
