11. Hyalinised glomeruli: Difference between revisions
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[[File:Hyalinised glomeruli - overview.png|thumb|Overview]]'''Staining''': HE | [[File:Hyalinised glomeruli - overview.png|thumb|Overview|356x356px]]'''Staining''': HE | ||
'''Organ''': Kidney | '''Organ''': Kidney |
Revision as of 13:35, 7 July 2024
Staining: HE
Organ: Kidney
Description:
Four typical signs can be seen:
- Most glomeruli contain globular eosinophilic structures. Some glomeruli are unaffected.
- The tubulointerstitium is infiltrated by RBCs, lymphocytes and plasma cells
- The tubules contain eosinophilic substance, making they look like the thyroid histologically. This process is called thyroidisation.
- Arteriolosclerosis of the vessels in the renal sinus
Diagnosis: End-stage chronic kidney disease
Causes:
- Diabetic nephropathy
- Chronic pyelonephritis
- Rapidly progressing glomerulonephritis
- Glomerulonephritis
Theory:
Hyalinisation of the glomeruli is the morphology of the end-stage kidney disease (chronic renal failure), which is often the end-result of the conditions mentioned above.
Despite the loss of many glomeruli some are still normal and functioning, so the kidney still produces some urine.